According to Xsoftspy and ZDnet, you can configure the settings to start scanning as soon as the program loads (see in the link the screenshot).... It is actually marketed for computer repair technicians so they can repair and remove infections with it. I have never heard yet of U3 itself getting infected while the drive is being presented to the OS. Read this review article:
http://blogs.zdnet
My technicians and I use it on a daily basis just to keep the Sandisk U3 drive protected since I actually use MalwareBytes AntiMalware for the repairs..... I have never had the U3 drive get infected (and we see a lot of machines every day)...





by: sirocco87Posted on 2009-09-27 at 11:29:55ID: 25434902
You can use the USB write protector: http://www.gaijin.at/dlusb wp.php
I don't know if your on-stick anti-virus apps will still work (they might have to write to the stick for updated definitions)
Hope that helps