Have a look at the BIN folder, there should be a (or some) assemblies the are "locked", that is, prevented from running because WIN2008 treats them as coming from a Network.
Check it by right clicking on the file and looking at the bottom of the popup window. After "unlocking" them, restart IIS and try again.
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by: MiamiDolphinsPosted on 2009-02-01 at 16:58:34ID: 23523825
i am running full trust by the way