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Blocking outgoing spam clients

Asked by murrayizzett in Anti-Spyware, Anti-Spam Email Software, Network Software Firewalls

Tags: spam, ISA server 2006, smtp, Win 2003, anti-virus

This exact same question has just been raised where the contributor had a Sonicwall firewall. The only difference with my issue is we use ISA 2006.

Our pubilc IP address has been blacklisted and I have detected the workstation from which the spam is coming from using ISA 2006 logging and reporting. It is most certainly a trojan or virus of some sort.

We use an off-site mail server so all users either connect with POP/SMTP using MS Outlook or the web mail GUI. All users have the same network configuration and are on the same Win 2003 domain. We use NOD32 for anti-virus.

I have used the following tools to successfully clean various machines that have had suspicious outbound smtp activity:
- Malwarebytes
- Spybot

However in the case of the one machine I am unable to stop the smtp activity using any of the antivirus or malware tools.

How do I address this: Should it be on the workstation or on the ISA server? In either event how do I prevent this from escalating?

Anxiously awaiting a response!
[+][-]06/30/09 04:54 AM, ID: 24744277Expert Comment

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[+][-]06/30/09 08:14 AM, ID: 24746128Expert Comment

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[+][-]09/12/09 02:17 PM, ID: 25317921Expert Comment

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