Malware, Trojan, something else?

So, I'm pretty sure I have some sort of Malware on my machine from the way my hard drive is accessing every second, and there's registry changes for some "system files" at startup, everytime I boot up.

First: Here's some of the registry changes from my Spybot SD TeaTimer log:
value "MSServer" (new data: "rundll32.exe C:\Windows\system32\cbxwu.dll,#1") changed in System Startup global entry!
value "MSServer" (new data: "rundll32.exe C:\Windows\system32\efcde.dll,#1") changed in System Startup global entry!
value "MSServer" (new data: "rundll32.exe C:\Windows\system32\vtuvu.dll,#1") changed in System Startup global entry!
value "MSServer" (new data: "rundll32.exe C:\Windows\system32\efecc.dll,#1") changed in System Startup global entry!

And now, here's my HijackThis! Scan:
Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 8:17:25 PM, on 12/18/2007
Platform: Windows Vista  (WinNT 6.00.1904)
MSIE: Internet Explorer v7.00 (7.00.6000.16575)
Boot mode: Normal

Running processes:
C:\Windows\system32\Dwm.exe
C:\Windows\system32\taskeng.exe
C:\Windows\Explorer.EXE
C:\Windows\system32\WTablet\Pen_TabletUser.exe
C:\Program Files\Windows Defender\MSASCui.exe
C:\Windows\System32\rundll32.exe
C:\Program Files\Java\jre1.6.0_03\bin\jusched.exe
C:\Windows\System32\oodtray.exe
C:\Program Files\Alwil Software\Avast4\ashDisp.exe
C:\Program Files\COMODO\Firewall\cfp.exe
C:\Program Files\Microsoft Office\Office12\GrooveMonitor.exe
C:\Program Files\Synaptics\SynTP\SynTPEnh.exe
C:\Windows\System32\rundll32.exe
C:\Program Files\Windows Sidebar\sidebar.exe
C:\Program Files\Wallpaper Master\Wallpaper.exe
C:\Program Files\Spybot - Search & Destroy\TeaTimer.exe
C:\Program Files\DAEMON Tools\daemon.exe
C:\Windows\System32\rundll32.exe
C:\Windows\System32\spool\drivers\w32x86\3\E_FATIBIA.EXE
C:\Program Files\Dell\QuickSet\quickset.exe
C:\Program Files\Windows Sidebar\sidebar.exe
C:\Windows\system32\wuauclt.exe
C:\Windows\system32\rundll32.exe
C:\Program Files\Pidgin\pidgin.exe
C:\Windows\System32\mobsync.exe
C:\Program Files\Mozilla Firefox\firefox.exe
C:\Users\Norumu\Desktop\HiJackThis.exe

R1 - HKCU\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,SearchAssistant =
R0 - HKLM\Software\Microsoft\Internet Explorer\Search,CustomizeSearch =
R0 - HKCU\Software\Microsoft\Internet Explorer\Toolbar,LinksFolderName =
O1 - Hosts: ::1 localhost
O4 - HKLM\..\Run: [Windows Defender] %ProgramFiles%\Windows Defender\MSASCui.exe -hide
O4 - HKLM\..\Run: [Adobe Reader Speed Launcher] "C:\Program Files\Adobe\Reader 8.0\Reader\Reader_sl.exe"
O4 - HKLM\..\Run: [NVHotkey] rundll32.exe C:\Windows\system32\nvHotkey.dll,Start
O4 - HKLM\..\Run: [SunJavaUpdateSched] "C:\Program Files\Java\jre1.6.0_03\bin\jusched.exe"
O4 - HKLM\..\Run: [OODefragTray] C:\Windows\system32\oodtray.exe
O4 - HKLM\..\Run: [avast!] C:\PROGRA~1\ALWILS~1\Avast4\ashDisp.exe
O4 - HKLM\..\Run: [COMODO Firewall Pro] "C:\Program Files\COMODO\Firewall\cfp.exe" -s
O4 - HKLM\..\Run: [GrooveMonitor] "C:\Program Files\Microsoft Office\Office12\GrooveMonitor.exe"
O4 - HKLM\..\Run: [SynTPEnh] C:\Program Files\Synaptics\SynTP\SynTPEnh.exe
O4 - HKLM\..\Run: [NvSvc] RUNDLL32.EXE C:\Windows\system32\nvsvc.dll,nvsvcStart
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE C:\Windows\system32\NvCpl.dll,NvStartup
O4 - HKLM\..\Run: [NvMediaCenter] RUNDLL32.EXE C:\Windows\system32\NvMcTray.dll,NvTaskbarInit
O4 - HKLM\..\Run: [nwiz] nwiz.exe /install
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\QTTask.exe" -atboottime
O4 - HKLM\..\Run: [MSServer] rundll32.exe C:\Windows\system32\efecc.dll,#1
O4 - HKCU\..\Run: [Sidebar] C:\Program Files\Windows Sidebar\sidebar.exe /autoRun
O4 - HKCU\..\Run: [WallpaperChanger] C:\Program Files\Wallpaper Master\Wallpaper.exe
O4 - HKCU\..\Run: [SpybotSD TeaTimer] C:\Program Files\Spybot - Search & Destroy\TeaTimer.exe
O4 - HKCU\..\Run: [DAEMON Tools Lite] "C:\Program Files\DAEMON Tools\daemon.exe"
O4 - HKCU\..\Run: [EPSON Stylus CX6000 Series] C:\Windows\system32\spool\DRIVERS\W32X86\3\E_FATIBIA.EXE /FU "C:\Windows\TEMP\E_S9E14.tmp" /EF "HKCU"
O4 - HKUS\S-1-5-19\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-19\..\Run: [WindowsWelcomeCenter] rundll32.exe oobefldr.dll,ShowWelcomeCenter (User 'LOCAL SERVICE')
O4 - HKUS\S-1-5-20\..\Run: [Sidebar] %ProgramFiles%\Windows Sidebar\Sidebar.exe /detectMem (User 'NETWORK SERVICE')
O4 - Global Startup: QuickSet.lnk = ?
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\Office12\EXCEL.EXE/3000
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0_03\bin\ssv.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.6.0_03\bin\ssv.dll
O9 - Extra button: Send to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~2\Office12\ONBttnIE.dll
O9 - Extra 'Tools' menuitem: S&end to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~2\Office12\ONBttnIE.dll
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~2\Office12\REFIEBAR.DLL
O9 - Extra button: (no name) - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O9 - Extra 'Tools' menuitem: Spybot - Search & Destroy Configuration - {DFB852A3-47F8-48C4-A200-58CAB36FD2A2} - C:\PROGRA~1\SPYBOT~1\SDHelper.dll
O13 - Gopher Prefix:
O16 - DPF: {D27CDB6E-AE6D-11CF-96B8-444553540000} (Shockwave Flash Object) - http://fpdownload2.macromedia.com/get/shockwave/cabs/flash/swflash.cab
O18 - Protocol: grooveLocalGWS - {88FED34C-F0CA-4636-A375-3CB6248B04CD} - C:\Program Files\Microsoft Office\Office12\GrooveSystemServices.dll
O20 - AppInit_DLLs:  C:\Windows\system32\guard32.dll
O22 - SharedTaskScheduler: Windows DreamScene - {E31004D1-A431-41B8-826F-E902F9D95C81} - C:\Windows\System32\DreamScene.dll
O23 - Service: avast! iAVS4 Control Service (aswUpdSv) - ALWIL Software - C:\Program Files\Alwil Software\Avast4\aswUpdSv.exe
O23 - Service: avast! Antivirus - ALWIL Software - C:\Program Files\Alwil Software\Avast4\ashServ.exe
O23 - Service: avast! Mail Scanner - ALWIL Software - C:\Program Files\Alwil Software\Avast4\ashMaiSv.exe
O23 - Service: avast! Web Scanner - ALWIL Software - C:\Program Files\Alwil Software\Avast4\ashWebSv.exe
O23 - Service: COMODO Firewall Pro Helper Service (cmdAgent) - COMODO - C:\Program Files\COMODO\Firewall\cmdagent.exe
O23 - Service: Intel(R) PROSet/Wireless Event Log (EvtEng) - Intel Corporation - C:\Program Files\Intel\Wireless\Bin\EvtEng.exe
O23 - Service: Dell Internal Network Card Power Management (nicconfigsvc) - Dell Inc. - C:\Program Files\Dell\QuickSet\NicConfigSvc.exe
O23 - Service: O&O Defrag - O&O Software GmbH - C:\Windows\system32\oodag.exe
O23 - Service: Intel(R) PROSet/Wireless Registry Service (RegSrvc) - Intel Corporation - C:\Program Files\Intel\Wireless\Bin\RegSrvc.exe
O23 - Service: SBSD Security Center Service (SBSDWSCService) - Safer Networking Ltd. - C:\Program Files\Spybot - Search & Destroy\SDWinSec.exe
O23 - Service: Steam Client Service - Valve Corporation - C:\Program Files\Common Files\Steam\SteamService.exe
O23 - Service: TabletServicePen - Wacom Technology, Corp. - C:\Windows\system32\Pen_Tablet.exe

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End of file - 7317 bytes

Any help would be appreciated, as I have no idea what I'm doing with most of this info, but I know something is wrong.Start Free Trial