1 Make sure you have Service Pack 2
2 If you're running Symantec Mail Security make sure you're on a current version, previous versions had issues
3 Make sure that you're not going over the mail store limit (SP2 for Exchange allows increase from 16GB with SP1 to 75GB but you need to modify registry keys, by default gives you 18GB after SP2 install)
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by: RobinHumanPosted on 2008-11-06 at 15:54:34ID: 22900920
This seems to be an issue relating to symantec mailsecurity - a bad update or something similar;
contact symantec support for a resolution.
Hope this helps