The major reason with regards to Exchange 2007 not supported on Windows 2008 R2 is compatibility issues with Powershell.
You can also try reinstalling the CAS role to check with the error
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Why am I getting a "Cannot write configuration file" error when trying to disable Compression on a website in IIS Manager?
I installed Microsoft Exchange 2007 SP1 on a Server 2008 R2 on a virtual machine. The domain controller is hosted on another VM. Databases and Logs are all kept on separate drives. When I access the Exchange Management Console I get the following warning:
--------------------------
Microsoft Exchange Warning
--------------------------
The following warning(s) were reported while loading topology information:
Get-OWAVirtualDirectory
Completed
Warning:
The virtual directory "Exchange (Default Web Site)" is not configured correctly. This server has the Mailbox server role installed, so HTTP compression must be disabled. You can use the IIS Manager to disable compression.
Warning:
The virtual directory "Public (Default Web Site)" is not configured correctly. This server has the Mailbox server role installed, so HTTP compression must be disabled. You can use the IIS Manager to disable compression.
Warning:
The virtual directory "Exchweb (Default Web Site)" is not configured correctly. This server has the Mailbox server role installed, so HTTP compression must be disabled. You can use the IIS Manager to disable compression.
--------------------------
OK
--------------------------
So I accessed the IIS Manager and tried to disable static compression on all three of the listed sites. When ever I try to hit 'Apply' I get the following error window:
Title: Compression
There was an error while performing this operation.
Details:
Filename: \\?\BackOfficeStorage\[myd
Error: Cannot write configuration file.
All I can do at this window is hit OK, and exiting discards changes.
What causes this error window to appear, and how can I fix this where Exchange no longer has any warnings?
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by: MesthaPosted on 2009-08-26 at 11:12:42ID: 25190535
"Microsoft Exchange 2007 SP1 on a Server 2008 R2"
That isn't a supported configuration.
Microsoft Exchange 2007 is not supported on Server 2008 R2.
You will need to remove Exchange and rebuild the box as Server 2008 with SP2.
Simon.