If you have a problem sending to any user on any domain, you will need to verify your Exchange configuration and connectivity including DNS configuration.
If you have a problem sending to a single domain only, or a few domains, while your other mail flows has no problems, them most probably you have a DNS issue.
Make sure your DNS server can resolve the MX records of the target domain.
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by: demazterPosted on 2009-10-25 at 00:52:02ID: 25655883
Do you receive a NDR message?
qs/readQue stion.php? qid=2
Have a look at this FAQ from alanhardisty: http://www.it-eye.co.uk/fa