have you looked at the IIS configuration like everything is congiured FQDN etc ? have you tried to open as https instead of http

hi

check http://www.isaserver.org/articles/exportsslcert.html

post back results

mattibutt:

I've tryed a number of things still no luck. I can access the web server from the TMG computers thats hosting it my typing http://srv-004, however unable to do that on any of the client machines.

unable to access the server my typing srv-004.domain-name.com either

i think in server 2008 it sets two names one for inernal use and one for external what did you put on external have put it on different ports to see the effect maybe the port is already used by something else

is your dns setting correct try to run nslookup from client machine to check your server dns settings

http://www.computing.net/answers/networking/cant-access-external-website/40133.html
can you have a look at this its basically saying the internal and external address should be different is that correct in your case?

mattibutt:

I did nslookup on a client machine and this is the resualts

C:\Docuements and Settings\admin>nslookup
***carn't find server name for address 10.0.0.10: None-existent domain
***Defualt server's are not available
Defualt Server: unknown
Address: 10.0.0.10

arnold:

How would I be able to try exempting local traffic from passing though the proxy server ? not 100% sure on doing that.

Yeah I think I can explain most of that becouse I have multipal DNS servers and it was very slow internet access with Forefront as my router has DNS my forefront has DNS and my domain controller has DNS aswell

Which has the DHCP server? You can configure the DHCP to include the settings for the DNS which should point the LAN systems to the DC/Domain DNS. External DNS does not have a wqy to resolve the localdomain.  You might want to point the forefront DNS to the Domain DNS servers.

Are you using a GPO to set the Proxy on the clients?
Within the same section where you define the proxy option, there is a section where you can exempt the LAN as well as specific sites from going through the proxy.