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As far as the in-place upgrade, you should be ok. Regarding Exchange, you will probably need to make some adjustments. Exchange features can be affected due to a major change like this.<br />
<br />
<a href="http://social.technet.microsoft.com/Forums/windowsserver/en-US/c28c2fdc-ad1f-49d4-aebe-ee8c0d374eed/2008-r2-2012-in-place-upgrade?forum=winserver8gen" rel="ugc nofollow">http://social.technet.microsoft.com/Forums/windowsserver/en-US/c28c2fdc-ad1f-49d4-aebe-ee8c0d374eed/2008-r2-2012-in-place-upgrade?forum=winserver8gen</a><br />
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Hope this helps!
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As far as the in-place upgrade, you should be ok. Regarding Exchange, you will probably need to make some adjustments. Exchange features can be affected due to a major change like this.

http://social.technet.microsoft.com/Forums/windowsserver/en-US/c28c2fdc-ad1f-49d4-aebe-ee8c0d374eed/2008-r2-2012-in-place-upgrade?forum=winserver8gen [http://social.technet.microsoft.com/Forums/windowsserver/en-US/c28c2fdc-ad1f-49d4-aebe-ee8c0d374eed/2008-r2-2012-in-place-upgrade?forum=winserver8gen]

Hope this helps!

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I have a single Exchange 2010 SP3 Server with all the roles running on Server 2008 R2 ‘Standard’. I want to setup DAG for redundancy but Standard Edition doesn’t support the Clustering Feature needed to implement DAG. It’s my understanding that Server 2012 Standard supports Clustering, would an in-place upgrade to Server 2012 ‘Standard’ be a viable solution? Has anyone out there had experience with doing an in-place upgrade with Exchange Server 2010 installed?
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I have a single Exchange 2010 SP3 Server with all the roles running on Server 2008 R2 ‘Standard’. I want to setup DAG for redundancy but Standard Edition doesn’t support the Clustering Feature needed to implement DAG. It’s my understanding that Server 2012 Standard supports Clustering, would an in-place upgrade to Server 2012 ‘Standard’ be a viable solution? Has anyone out there had experience with doing an in-place upgrade with Exchange Server 2010 installed?

In-Place upgrade from Server 2008R2 to Server 2012 with Exchange 2010 installed

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Windows Server 2008 and Windows Server 2008 R2, based on the Microsoft Vista codebase, is the last 32-bit server operating system released by Microsoft. It has a number of versions, including including Foundation, Standard, Enterprise, Datacenter, Web, HPC Server, Itanium and Storage; new features included server core installation and Hyper-V.

Windows Server 2008

Windows Server 2012 is the server version of Windows 8 and the successor to Windows Server 2008 R2. Windows Server 2012 is the first version of Windows Server to have no support for Itanium-based computers since Windows NT 4.0. Windows Server 2012, now in its second release (Windows Server 2012 Release 2) includes Foundation, Essentials, Standard and Datacenter, and does not support IA-32 or IA-64 processors.