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A reboot isn't necessary or even desirable. If there's an error in the cf file and you do it while the system is running, you'll know about it right then. It's easy to miss the error when the system is booting.
After you change the sendmail.cf all that you need to do is kill and restart sendmail. The easiest way to do this on most Linuxen is to just invoke the system init script with a restart option (or a stop followed by a start if your init script doesn't provide a restart). For instance on RedHat 6.1 I'd do (as root) "/etc/rc.d/init.d/sendmail
After you change the sendmail.cf all that you need to do is kill and restart sendmail. The easiest way to do this on most Linuxen is to just invoke the system init script with a restart option (or a stop followed by a start if your init script doesn't provide a restart). For instance on RedHat 6.1 I'd do (as root) "/etc/rc.d/init.d/sendmail
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