I am running II 4.0 on NT server 4.0 SP5 with Exchange Server 5.5. I am using a simple CDONTS.sendmail from an asp. SMTP is not setup under IIS but is under Exchange server. The DLL is fully registered and the winnt/systems32 directory is allowing read/write permissions to the system user (NTFS file system). Are the dependencies outside of the system32 directory that need permission changes? I had to manually register the cdonts.dll even though it should have been registered by exchange server. Any suggestions?