Problem installing VB6 application on Windows 2000

We have a VB6 application that has installed successfully on a variety of desktops. However we have one machine running Windows 2000 that the installation fails.
We see the temporary files being copied (7 of them) but then take an error:

"Can not start main setup program"
0X000000C18

I am assuming that the later is a location.
Any ideas anyone?
This application has been installed successfully from the server for 3 years so it must be some kind of environmental conflict.
Thanks,
Bob O'M>
rwomalleyAsked:
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