Stop: 0x0000000A, datestamp - ptserial.sys

I get this eror constantly, and I am unsure f how to fix it. When the BSOD occurs, I do not get any information on what is loading, I only get information about dumping physical memory.  My error references Stop: 0x0000000A, ....address BCF.. base BCF92000, Datestamp - ptserial.sys.  Is this telling me that the ptserial.sys driver is causing this problem?  The drivers used for my mouse are sermouse.sys and mousclass.sys.  Furthermore, when I look at my registry keys, I find that there is references to ptserial.sys, looking like this:
HKEY_CURRENT_USER\Software\Microsoft\Internet Explorer\Explorer Bars\
{C4E****F3-4768-****-***C-00A****83DA1}\FilesNamedMRU, and the values are:
                          Default REG_SZ (value not se)
                          000 REG_SZ sermouse.sys
                          001 REG_SZ ptserial.sys

I run Win2K platform with the following IRQS assigned:


IRQ Number Device
9          Microsoft ACPI-Compliant System
11         ASUS V8200 Series v21.81a
11         SIIG CN2487 UDMA133 IDE Adapter
11         KTI KF-230TX/Base-TX Fast Ethernet Adapter
11         3Com EtherLink XL 10/100 PCI NIC (3C905-TX)
11         HSP56 MicroModem
11         Win2000 Promise Ultra100 (tm) IDE Controller 11         VIA USB Universal Host Controller
11         VIA USB Universal Host Controller
11         VIA USB Universal Host Controller
11         VIA AC'97 Enhanced Audio Controller (WDM)
14         Primary IDE Channel
15         Secondary IDE Channel
8          System CMOS/real time clock
13         Numeric data processor
6          Standard floppy disk controller
4          Communications Port (COM1)
3          Communications Port (COM2)
1          ASUS OSD PS/2 Keyboard Filter Driver
10         MPU-401 Compatible MIDI Device

I understand that IRQ 11 is darrying a load, but I do not use the two NICs at this time.  I have been having this problem for some time now, and I don ot remember when it started, or what additions to the system I may have made (dumb not to take note, huh?)
I do not get any errors on boot, but I will get the error when, after running the machine for any length of time, I double-click my desktop shortcut for NetZero, and sometimes when I am doing alot of work on the computer, the screen will freeze and I have to reboot.

I know I have all the information here to fix the problem,, but I am just a little unsure of what to do.  I feel like I should just delete the ptserial.sys dll and any references to it in my registry.  Can you help?