Exch2003/Win2003 troubleshooting help

I installed the above combination a few months back and tested the web outlook client and was able to send/receive email.  Since then, I went ape and installed and played with Share Point 2002 beta.  I don't know if Share point is related to my problem, but currently, all email is going to my draft folder and not sending. I'm also unable to receive.

Remotely I tried to "Telnet domainname.com 25" and getting unable to open connection on port 25, connect failed.

I confirmed that Port 25 is routing to the correct box.  

I've confirmed that the SMTP server is up and running.  On the server itself, I can get back a positive connection performing telnet.  But I'm cluess how to preceed or troubleshoot.  What should I trouble shoot next?

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