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Small Business Server 2000 requiring reboot every day to restore access for clients to exchange backup etc

Small Business Server 2000, SP4, running veritas backup exec, McAfee EPO. Clients utilising ISA server for internet access. Following a reboot the server works fine, however, through the day the server loses certain functionality,examples are, internet access icons show no activity despite being connected and active (never seems to disconnect), if you right click on them to disconnect it will not disconnect.  Right click within event viewer does not display the properties window as expected, however, when the event viewer is closed a message appears requesting all property windows are closed before closing the event viewer.  Also backups are failing to read media.  Within active directory, if you right click for properties when logged in as administrator it says you do not have permission to view this item.  All these functionalities return if the server is rebooted.
We have used various tools looking for adware/spyware etc and the server is virus free according to McAfee.

any suggestions on where to try next would be greatly appreciated.
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Zaheer Iqbal
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Try running an online check http:\\housecall.trendmicro.com
Also is there any errros in the event viewer log..
Also are you updated with ISA server service packs??
http://www.isaserver.org/pages/bugs/patches.asp
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ASKER

I've had  a suggestion from a fellow IT engineer (MCSE) that it may be related to a corrupt mfc42.dll file, I have compared the file on my workshop server and the size is 973K in comparison with 992K on the faulty server, does this suggest there is something attached to the original dll?, I will try replacing this file on wednesday evening when on site and report results. Also suggested to check RPC server. Any comments on following this track?
Again if the dll is larger also check the version number.. Mfc42.dll is used by many programs too.
Double check the versions...
We've re-installed IE6 and relevant patches this appears to fixed the problem but time will tell.
thanks for your help 1stITMAN, although your answers did not solve the problem directly they were helpful.
No Probs...
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PashaMod

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