Serial Port not working

I cannot HotSync my palm pilot with my computer unless i disable the serial port then reinable the port then I can hotsync it. I have a Palm IIIxe with the serial cable.  I have a e-machines computer t2082.  I was able to hotsync when i first got the computer but now i get the message that "Hotsync will be available when the port becomes available."
How can i repair this problem?
pjgoossenAsked:
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CallandorConnect With a Mentor Commented:
You may have some other application grabbing control of the serial port.  Take a look at what gets automatically started, and you will probably find something that uses the serial port.  It's probably not relinquishing it, so Palm can't get control of it.
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