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Exchange 2000 - Blacklisted and SMTP queues piling up

My domain has two Exchange server in two different locations

I have turned off open relaying on both and Access Authentication has been checked

I am not sure why but my SMTP queues are piling up and my Exchange server is slowing down.

Help.

Steve

Note: Windows 2000 Server, Exchange 2000 SP4
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Sembee
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As far as the NDR attack is concerned the email addresses are not being spoofed to be real sent froms. So could this still be a possiblity?

I do not believe that anyone is collecting email through OE.

Finally We are not using SBS, is there anyway to clean the queues within Exchange Server 2000?

Thanks,
Steve
I should have said ignore the SBS reference as it is the same technology - SBS uses Exchange. I don't think there is a version of the article just for Exchange.

Simon.