how to save changes made in picture box

i am using picture box tool(visualbasic-6) for displaying images on a form and  i want to know how can i save the changes that  made for the image in the picture box in runtime .I am able to save the picture but i an not getting the changes made on the image in my saved file. I am using Visual basic6.

suppose if we took a man image with out nose i am lodint the image on to the picture box. when i run the file then i am adding the nose to the picture and saving it.but in my saved file i am not getting his nose but getting the old file with out nose only. i want his nose to be also save in the new file but i am not ablt to do. so how can i do that
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A bit tricky, but here it goes :

Private Sub Command1_Click()
   Picture1.AutoRedraw = True                 ' this is the important line !!!!
   Picture1 = LoadPicture("the initial one.bmp")
   Picture1.Circle (100, 100), 200, vbRed    ' draw a circle, not a nose !
   Picture1.Picture = Picture1.Image
   SavePicture Picture1, "the new one.bmp"
End Sub

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