ISA 2004 Problem with POP3 Clients

Hi, I have ISA 2004 with Small Business Server 2003, the workstations are Win Xp PRO with Outlook 2003 doing POP3 to the ISP. I have a rule created for POP3 and no body can download e-mails, keep telling:
(Receiving' reported error)(0x80042108) : 'Outlook is unable to connect to your incoming (POP3) e-mail server. If you continue to receive this message, contact your server administrator or Internet service provider (ISP).'the POP3 Sever is no available.

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