PDC with AD.

Have 300 users and 14 Administrators.

Can I set up different GPO's for user's in the same domain.

1 for users and 1 for Administrators?

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Yes - Create two different OUs one for USERS and one for ADMINISTRATORS - Then you can apply different

In Active Directory Users and Computers - Right click on your Domain Name - NEW - Organizational Unit

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Download the GPMC (Group Policy Managment Console) from Microsoft.
With this you can manage Policies very easier as in AD Users and Computers.
There you can drag&drop your Policies onto the OU's you want them.
btw, you can link Policies to Sites too (if you use sites).
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Windows Server 2003

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