I have 20 Mac users who frequent my 2003 NAS via SMB connection. If they mistakenly open the file directly off the server, their Photoshop and Illustrator applications bring the server to its knees.
They SHOULD be staging files to their workstation and working locally. When complete, they should be copied back.
This is probably too much to ask for....Any possibility of preventing them from executing the file and only allowing a copy?