SMTP Protocol Returned a Permanent Error 554 mail server permanently rejected message (#5.3.0)

I have a user that is not getting some e-mails from the outside. The people sending him e-mails receive a NDR with this error.

Delivery Failure Report Your document:  Re: Fw: Tonight!  
was not delivered to:  user@mydomain.com  
because:  Error transferring to emailserver.MYDOMAIN.COM; SMTP Protocol Returned a Permanent Error 554 mail server permanently rejected message (#5.3.0)

I looked it into and according to microsoft (http://support.microsoft.com/?kbid=895857) the issue lies in my firewall configuration which we just migrated about 2 months ago. I submitted a ticket with Cisco and I am waiting to hear back.

However, has anyone seen this error and knows what else might contribute and what else I can do to rectify this.
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InfinityinfoAsked:
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northcideCommented:
Make sure the SMTP FIXUP is not enabled on the PIX
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