I have two different networks with the same situation, one is Exchange 2003, and the other is Exchange 5.5. Both are setup such that Exchange handles only internal messaging. No internet mail service or smtp connectors are setup. Internet email is handled by the Outlook clients via pop3 but store all mail in the Exchange mailbox. My question is if the Out of Office assistant can reply to internet email in this configuration, or does internet mail have to be setup on the Exchange server?