SMTP Queue (Remote Delivery)

I have my SMTP queue filling up with queues for mail going to false domains.  Right now I have over 400 remote delivery queues.  

Where are all the places that I should check on my exchange server 2000 to make sure that my server isn't sending NDR or trying to tell the sender that the indended receipent isn't on my system.  This might make things flow better  My spam filter might also be generating them also, I'm going to test it by turning it off for a day also to see if these queues clear up.

Thanks in advance.
ZantisAsked:
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rakeshmiglaniConnect With a Mentor Commented:
Check the following articles. They are pretty good.

Are you an Open Relay?
http://www.amset.info/exchange/smtp-openrelay.asp

NDR and Open Relay Spam Clean Up
http://www.amset.info/exchange/spam-cleanup.asp

Filter Out Mail to Non-Existent Users
http://www.amset.info/exchange/filter-unknown.asp
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