troubleshooting Question

Outside email getting blocked. Error Transferring to; SMTP Protocol retured a permanent error 550 relay not permitted

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bornhusker asked on
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We have a Windows SBS 2003 server that appears to be blocking one sending domain. The delivery failure report they receive (the sending email address) gives the following reason for the failure:
Error transferring to; SMTP Protocol Returned a Permanent Error 550 relay not permitted.

Does anyone know what could be causing these bounce backs from this domain.
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