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Large emails stuck in exchange back end queue

Hello,

My backend emails server processes about 50,000 emails a day and about 5 get stuck in the "messages awaiting directory lookup" queue.  All the messages that get stuck are 3 to 10 megs in size.  I have checked the size settings everywhere I can and don't see any limits close to this and some emails this size are getting through ok.  My other backend server does not seem to be affected.  I am running symantec AV and GFI tools on all my Exchange servers.
I have tried to disable Symantec and the queue does not seem to clear.

Can someone tell me where to look to try to make sure the messages flow right through?

Thank you.
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Sembee
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ASKER

Just for follow up and closure, I am fine giving the points to sembee and appologize for the slow response.

I tried to adjust my Symantec AV to exclude every directory, but even when it was disabled large emails would get stuck.  Unfortunately emails appear to still be delayed so you are correct that the queues does seems to work only when the AV is completely removed.   Emails have not been getting "stuck" for several days now when before they would get stuck every couple hours.

Thank you for the responses.

-craig