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troubleshooting Question

CRM application for investment banking (of-the-shelf & in-house)

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I am looking for an efficient CRM application for investment banking. I work in an investment bank that is not happy with the in-house developed application.
1- What of-the-shelf applications do you recommend?
2- What are the advantages/disadvantages, and limitations of handling our CRM in an in-house developed application?
3- I need a comparison table that illustrates the difference between of-the-shelf & in-house CRM applications.
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