Exchange 2000 SP3 on W2K SP4 550 5.7.1 Requested action not taken, Message refused

I've been working on a box that has W2K server SP4 and Exchange 2K SP3 on it.  people who send e-mail to us randomly get NDRs that say 550 5.7.1 Requested action not taken, Message refused.  The same  person could e-mail again 4 senconds later and it would work fine... it's too intermitent to test... and most of what I have read keeps pointing toward the antivirus scanning the mail or the M: drive.  well... until I was messing with it, nothing had been changed with the antivirus in a long time.  so it doesn't really make sense that it would suddenly start doing this.  any other idea that might shed some light on this?
cymrichAsked:
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redseatechnologiesCommented:
>>well... until I was messing with it, nothing had been changed with the antivirus in a long time.  so it doesn't really make sense that it would suddenly start doing this.

That doesn't matter, anti-virus will occasionally just start doing stupid things.

I have a site here where the AV scanner went nuts and started holding onto random items in the queue - after working fine for years.

Can you check the logs of the AV system or exchange (message tracking) and see if you have any records of these touching your server?

I this one person having an issue sending to you, or is it more widespread?
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cymrichAuthor Commented:
I can check tomorrow.  It's much more widespread... but totally random... the only people that it happens to more than once are the people that e-mail addresses on the server frequesntly (so far).  I didnt think to look at AV logs, but I did search through event logs and checked the AV settings to ensure it was what it was supposed to be.
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redseatechnologiesCommented:
The randomness makes it difficult to work with, and difficult to test - as well as squarely point the finger at the AV scanner.  If it is weird, chances are it is the AV system - increases in weirdness increase that probability.

If you have good desktop protection, you could uninstall the AV scanner (disabling it is not enough) - alternatively, get a demo of GFI scanning software, install it on a gateway device and then take AV off the server itself.

It all depends on your user count, and their viral intelligence
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cymrichAuthor Commented:
Before I posted this I had already tried re-installing the AV.  that does seem to have fixed the issue, it was so intermitent though that I really wasnt conviced it was going to fix it.
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cymrichAuthor Commented:
I got interupted while typing the post above and must have hit submit by accident.  In any case... they have not had the issue since I reinstalled the AV.
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redseatechnologiesCommented:
Another reason why I dislike anti-virus programs, they are like airbags that randomly punch you in the face - sure it is additional security, but taking your chances and avoiding the punches certainly looks appealing sometimes...
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