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Attachment Corruption

Exchange 2k3, sp2 on windows server 2k3 sp2.
We had an attachment corruption problem with exchange that we thought was cleared up after an exchange hotfix, however, we are still having problems.  The corruption only happens when sending out of our domain.
Corruptions:  Most powerpoints, pdf's (this was fixed with the hotfix), some word, some excel, and now has corrupted a .wma file!
We applied a hotfix that seemed to help, we have changed routing groups, we have installed a new smtp virtual server.  We have also changed some settings on the NIC card, but that did not change anything.
Two servers on site, one of them sends corrupted attachments the other does not.
This all started after moving exchange to a new server.  Bad installation?  We had several other issues that required attention after the move also...
Microsoft has been unable to resolve so far.
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We have been down every road I could imagine other than a reinstall.  Antivirus is uninstalled, firewall is not a factor, spam filter does not scan outgoing email.
"..spam filter does not scan outgoing email."

As long as the spam filter touches the mail in any way it can cause problems, even if it is just changing the mail header in the most trivial way.
Not an issue.  It only scans incoming email.  Our problem ONLY happens when sending the attachments outside of our domain, and email going out does not get scanned.  
Where is the antispam filter? Is it installed on the Exchange server or a separate box?
Whether or not you have configured it to scan just inbound traffic, if email goes through the same physical machine it could still cause a problem. All that is happening when you configure a filter to work in one direction is that the email is left alone - the application still does its thing and can still cause a problem.

Simon.
It is a separate box.
Spent all day on the phone with Microsoft again.  They concluded it is not exchange.  Looks like it may be our ISP.  We are going to look at getting a new ISP and see what happens.
MS has resorted to reinstalling exchange and IIS, we will be doing that tomorrow.  I am certain this will fix our issues.
Sure hope so...
Totally reinstalled IIS and exchange + sp2 - did not fix the attachment corruption problems.  So, as MS has been saying from the very start (and you exchange experts) - it is NOT exchange.  We will most likely try a new ISP first, then maybe look at the firewall.
A reasonable thing. More and more ISP's are messing with outgoing mail these days in an attempt to reduce spam, but re-reading your original message I notice that one of your servers does not have this problem. Is that one using a different ISP?
Yes, it has its own outbound internet feed.
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Thanks for the update. Very glad you got it solved.