Outlook closes as soon as it starts

When I start Outllok 2007 I get a message bubble in the system tray saying"A data file did not close properly last time it was used and is being checked for errors".

Then outlook opens and after a few seconds closes

It creates the following in event viewer:

The content source <mapi://{s-1-5-21-203667054-2063414239-695505244-1000}/> cannot be accessed.

Context: Windows Application, SystemIndex Catalog

Details:
      A server error occurred. Check that the server is available.   (0x80041206)


The XML view of this is:

- <Event xmlns="http://schemas.microsoft.com/win/2004/08/events/event">
- <System>
  <Provider Name="Microsoft-Windows-Search" Guid="{CA4E628D-8567-4896-AB6B-835B221F373F}" EventSourceName="Windows Search Service" />
  <EventID Qualifiers="32768">3036</EventID>
  <Version>0</Version>
  <Level>3</Level>
  <Task>3</Task>
  <Opcode>0</Opcode>
  <Keywords>0x80000000000000</Keywords>
  <TimeCreated SystemTime="2007-08-09T08:43:58.000Z" />
  <EventRecordID>13212</EventRecordID>
  <Correlation />
  <Execution ProcessID="0" ThreadID="0" />
  <Channel>Application</Channel>
  <Computer>Isense01</Computer>
  <Security />
  </System>
- <EventData>
  <Data Name="ExtraInfo">Context: Windows Application, SystemIndex Catalog Details: A server error occurred. Check that the server is available. (0x80041206)</Data>
  <Data Name="URL">mapi://{s-1-5-21-203667054-2063414239-695505244-1000}/</Data>
  </EventData>
  </Event>

I've tried creating a new profile at start-up with no email, but I still get the same failure.

My normal profile connects to an exchange mailbox on my ISP.  OUltook on my other PC connects to this as normal.