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I would suggest you get additional disk and move your logs off the C drive...... for a number of reasons
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I would suggest you get additional disk and move your logs off the C drive...... for a number of reasons

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We are running exchange 2000 for our emails. Our exchange binaries, queues, and transaction logs are placed in C:\exchsrvr directory. The exchange information stores, both private and public, are stored in drive E. <br />
Can we defragment our C drive using the conventional file system defragmentation ?
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We are running exchange 2000 for our emails. Our exchange binaries, queues, and transaction logs are placed in C:\exchsrvr directory. The exchange information stores, both private and public, are stored in drive E. 
Can we defragment our C drive using the conventional file system defragmentation ?

Exchange, Defragmentation

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Within Internet message handling services (MHS), a message transfer agent or mail transfer agent (MTA) or mail relay is software that transfers electronic mail messages from one computer to another using a client–server application architecture. A MTA implements both the client (sending) and server (receiving) portions of the Simple Mail Transfer Protocol (SMTP). The terms mail server, mail exchanger, and MX host may also refer to a computer performing the MTA function. The Domain Name System (DNS) associates a mail server to a domain with mail exchanger (MX) resource records containing the domain name of a host providing MTA services.

Email Servers

Active Directory (AD) is a Microsoft brand for identity-related capabilities. In the on-premises world, Windows Server AD provides a set of identity capabilities and services, and is hugely popular (88% of Fortune 1000 and 95% of enterprises use AD). This topic includes all things Active Directory including DNS, Group Policy, DFS, troubleshooting, ADFS, and all other topics under the Microsoft AD and identity umbrella.