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This is not as specific as you wish but:<br />
<br />
Security hardening exchange servers:<br />
<a href="http://technet.microsoft.com/en-us/library/bb125085.aspx" rel="ugc">http://technet.microsoft.com/en-us/library/bb125085.aspx</a><br />
<br />
Tarpitting<br />
<a href="http://support.microsoft.com/kb/842851" rel="ugc nofollow">http://support.microsoft.com/kb/842851</a><br />
<br />
Consider Forefront for exchange, or Exhange Hosted Services for delux email 'cleansing' from microsoft.
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This is not as specific as you wish but:

Security hardening exchange servers:
http://technet.microsoft.com/en-us/library/bb125085.aspx [http://technet.microsoft.com/en-us/library/bb125085.aspx]

Tarpitting
http://support.microsoft.com/kb/842851 [http://support.microsoft.com/kb/842851]

Consider Forefront for exchange, or Exhange Hosted Services for delux email 'cleansing' from microsoft.

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I'm running Exchange 2003 on a Windows 2000 server. Our queue usually have a few thousand messages &quot;Delivery Status Notification (failure)&quot; bound for spammers. They guess names and tack it on our our domain name. These addresses don't exist and Exchange wants to send a message back. These sit in the queue until they time out. How do I not send replies to bad email addreses? 
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I'm running Exchange 2003 on a Windows 2000 server. Our queue usually have a few thousand messages "Delivery Status Notification (failure)" bound for spammers. They guess names and tack it on our our domain name. These addresses don't exist and Exchange wants to send a message back. These sit in the queue until they time out. How do I not send replies to bad email addreses? 

How to sending failure message to spammers

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.

Exchange

Windows 2000 is an operating system for use on both client and server computers. It is the successor to Windows NT 4.0, and is the last version of Microsoft Windows to display the "Windows NT" designation. Four editions of Windows 2000 were released (Professional, Server, Advanced Server, and Datacenter Server) that shared a core set of features, including many system utilities such as the Microsoft Management Console. All versions of the operating system support NTFS 3.0, Encrypting File System, as well as basic and dynamic disk storage. The Windows 2000 Server family includes support for Active Directory services, Distributed File System and fault-redundant storage volumes.