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Compatibility of Windows 2003 64 Bit in a 32 bit enviroment

Is there any compatibility issues with putting a new Windows 2003 64 bit system into an existing Windows 2003 domain with servers running standard 32Bit?
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If you're introducing a 64-bit domain controller into a domain that already has 32-bit DCs, you'll need to re-run adprep /domainprep and /forestprep from the 64-bit media.  

Printer drivers and software for other peripherals can be...challenging...if that's applicable to your environment.

Aside from that I haven't found anything specific to the Windows OS that causes issue, mostly compatibility with 3rd-party apps being compatible or not with the 64-bit architecture.