Computer Security and Scanning

Can anyone tell me how to scan my computer to see if some sort of spy ware or key logger is instaled? Not the run of the mill spyware, I have Symantic End Point as well as others for them what Im looking for is if some one may have got onto my computer and installed or setup somthing. Their are many that once installed wont show in program files dir, nor will they show in the add/remove.
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Dave HoweConnect With a Mentor Software and Hardware EngineerCommented:
The sysinternals site has three good tools for this; in order:

Process explorer - shows what is currently running. doesn't show dll injection and so forth:

Autoruns - shows what programs are set to autorun on machine boot:

RootkitRevealer - shows any programs trying to hide themselves from the first two tools. this is the tool that was used to discover the sony rootkit being added by various music cds...:
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