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How do your users book the resource? We normally have them only book resources via a meeting request sent to the resource mailbox. Therefore our users only have view access to open the calendar so they can see what's booked but to book a time they need to create a meeting request and include the resource mailbox as an attendee.
The resource mailbox is set to accept, etc via outlook. You can also consider using the auto-accept agent: -
http://technet.microsoft.com/en-us/library/aa996253.aspx