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What are the addresse that are being used by these programs? Are they related to your address space? Are there real accounts created for these programs? If filters are configured, Exchange will block or deny relay of any email sent from users that don't belong to active directory domain.<br />
From your descriprion, i guess your programs are being denied relay, cause you can send to your active directory accounts and that's normal cause it's local, but outside your domain is considered relay. So make sure that those programs are using you name space *@mydomain.com or there are actually real accounts created for these programs.<br />
Hope i was helpfull.
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What are the addresse that are being used by these programs? Are they related to your address space? Are there real accounts created for these programs? If filters are configured, Exchange will block or deny relay of any email sent from users that don't belong to active directory domain.
From your descriprion, i guess your programs are being denied relay, cause you can send to your active directory accounts and that's normal cause it's local, but outside your domain is considered relay. So make sure that those programs are using you name space *@mydomain.com or there are actually real accounts created for these programs.
Hope i was helpfull.

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I have a server running Server 03 and Exchange 2007. &nbsp;<br />
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I am having trouble sending emails from programs to anyone outside of our active directory domain.<br />
We can send and receive email normally through email clients like outlook, or outlook web access. &nbsp;Its just programs that are having trouble sending these emails.<br />
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The programs we use are developed in PHP and the php.ini has the address of our Exchange server listed as the SMTP server.<br />
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I have a server running Server 03 and Exchange 2007.  

I am having trouble sending emails from programs to anyone outside of our active directory domain.
We can send and receive email normally through email clients like outlook, or outlook web access.  Its just programs that are having trouble sending these emails.

The programs we use are developed in PHP and the php.ini has the address of our Exchange server listed as the SMTP server.



SMTP emails being sent by programs not being delivered to outside domains

Within Internet message handling services (MHS), a message transfer agent or mail transfer agent (MTA) or mail relay is software that transfers electronic mail messages from one computer to another using a client–server application architecture. A MTA implements both the client (sending) and server (receiving) portions of the Simple Mail Transfer Protocol (SMTP). The terms mail server, mail exchanger, and MX host may also refer to a computer performing the MTA function. The Domain Name System (DNS) associates a mail server to a domain with mail exchanger (MX) resource records containing the domain name of a host providing MTA services.

Email Servers

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.