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My company uses TrendMicro's Interscan Viruswall for our email gateway. &nbsp;Right now, it is running on a dedicated machine with an internal address of x.x.x.11. &nbsp;Our website runs on a machine with an internal address of x.x.x.4. &nbsp;Our Pix directs port 80 &amp;&nbsp;443 to x.x.x.4 and port 25 to x.x.x.11.<br />
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I want to decommission the dedicated Interscan machine and move the gateway to my webserver box which has dual NICs. &nbsp;I have reconfigured my Exchange SMTP virtual server to use port 26 internally, and have configured both my old Interscan boxes to forward mail to Exchange on port 26. &nbsp;<br />
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I have been able to recieve incoming email OK in this configuration, but have not been able to get outgoing to send from the webserver. &nbsp;It seems that the machine wants to send using the x.x.x.4 NIC which our Pix is blocking. &nbsp;Short of changing my firewall rules, is there a way to tell Server 2003 R2 to use NIC x.x.x.11 for port 25 traffic and x.x.x.4 for web traffic?
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My company uses TrendMicro's Interscan Viruswall for our email gateway.  Right now, it is running on a dedicated machine with an internal address of x.x.x.11.  Our website runs on a machine with an internal address of x.x.x.4.  Our Pix directs port 80 & 443 to x.x.x.4 and port 25 to x.x.x.11.

I want to decommission the dedicated Interscan machine and move the gateway to my webserver box which has dual NICs.  I have reconfigured my Exchange SMTP virtual server to use port 26 internally, and have configured both my old Interscan boxes to forward mail to Exchange on port 26.  

I have been able to recieve incoming email OK in this configuration, but have not been able to get outgoing to send from the webserver.  It seems that the machine wants to send using the x.x.x.4 NIC which our Pix is blocking.  Short of changing my firewall rules, is there a way to tell Server 2003 R2 to use NIC x.x.x.11 for port 25 traffic and x.x.x.4 for web traffic?

How do I setup machine to direct port 25 traffic to a particular NIC in a dual-homed machine

Networking hardware includes the physical devices facilitating the use of a computer network. Typically, networking hardware includes gateways, routers, network bridges, modems, wireless access points, networking cables, line drivers, switches, hubs, and repeaters. But it also includes hybrid network devices such as multilayer switches, protocol converters, bridge routers, proxy servers, firewalls, network address translators, multiplexers, network interface controllers, wireless network interface controllers, ISDN terminal adapters and other related hardware.

Networking Hardware-Other

Windows Server 2003 was based on Windows XP and was released in four editions: Web, Standard, Enterprise and Datacenter. It also had derivative versions for clusters, storage and Microsoft’s Small Business Server. Important upgrades included integrating Internet Information Services (IIS), improvements to Active Directory (AD) and Group Policy (GP), and the migration to Automated System Recovery (ASR).

Windows Server 2003

Exchange is the server side of a collaborative application product that is part of the Microsoft Server infrastructure. Exchange's major features include email, calendaring, contacts and tasks, support for mobile and web-based access to information, and support for data storage.