smtp relay in active directory site to edge transport server

All my mail stays in queue with the following error message:

<451 4.4.0 Primary target IP address responded with: "421 4.4.2 Connection dropped." Attempted failover to alternate host, but that did not succeed. Either there are no alternate hosts, or delivery failed to all alternate hosts.>

Receiving mail is no problem.

Situation: exchange server [hub+mail role] , edge [edge role] both have Exchange SP1 installed.
Servers are both replying with "220" on port 25 so this is not a problem.


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nbommeljeAuthor Commented:
After reboot the systeem sends out the compleer Queue. Al new mails then are again being Queued.
Vadim RappCommented:
Maybe your firewall is blocking outbound connections. Try to telnet from this machine to some smtp host on port 25.
nbommeljeAuthor Commented:
All communication from and to any port 25 is working. I can setup smtp from the exchange server 2 edge en from edge 2 internet. I've tried to check what is happening with the smtp communication between the exhange and the edge by adding a new send connector that resides on the exchange.

When I look at the logs on both side I see the following.

On the exchange side sendlog:
"220 Microsoft ESMTP MAIL Service ready at Fri, 15 Feb 2008 07:49:32 +0100",
<, Hello [x.x.x.x],
<,250-SIZE 10485760,
<,250-X-EXPS NTLM,
<,250 XEXCH50,
<,220 2.0.0 SMTP server ready,
*,,Sending certificate
*,,Certificate subject
*,"CN=CertServer, DC=domain1, DC=com",Certificate issuer name
*,**********************,Certificate serial number
*,*******************************************,Certificate thumbprint
*,,Certificate alternate names
On the edge side rec. log:
*,SMTPSubmit SMTPAcceptAnySender SMTPAcceptAuthoritativeDomainSender AcceptRoutingHeaders,Set Session Permissions
,>,"220 Microsoft ESMTP MAIL Service ready at Fri, 15 Feb 2008 08:00:33 +0100",
,>, Hello [x.x.x.x],
,>,250-SIZE 10485760,
,>,250-X-EXPS NTLM,
,>,250 XEXCH50,
,>,220 2.0.0 SMTP server ready,
,*,,Sending certificate
,*,CN=edge,Certificate subject
,*,CN=edge,Certificate issuer name
,*,********************************,Certificate serial number
,*,****************************************,Certificate thumbprint
,*,edge;,Certificate alternate names

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Tim HolmanCommented:
So when you reboot, all the mails send themselves without problems?  Is rebooting your current workaround?  
The message you're getting is saying your SMTP connection was established, but dropped, probably as things were getting too busy.
You could try this - not sure if it's the same with Exch 2007 but worth a try:

nbommeljeAuthor Commented:
I don't think the server is to busy with only 2 test email adresses. And only one or 3 mails stuck in the queue. I think I have to search the problem some where in certificates.
nbommeljeAuthor Commented:
SMTP was not working properly, Solution was removing Exchange, Windows server 2003 and the partition and installing everything new.

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