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Microsoft Entourage and Ports

My MAC users use Microsoft Entourage for email.  When they launch their VPN client Entourage does not work over the VPN.  What ports need to be opened and are they TCP or UDP?

My firewall is a ASA 5510 by Cisco

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Are they using pop3, IMAP, or have you configured RPC/HTTPS proxy on the Exchange server?  If you set up RPC/HTTPS proxy your Entourage clients should not need to use the VPN at all - They connect through port 443.  To set up the RPC/HTTPS proxy correctly however you need to set specific ports on your Exchange server registry -
If using the VPN however, enter the internal IP address of the Exchange server in the hosts file of the client computer.