Update & Delete from multiple tables in PHP?

How do I update & delete from multiple tables in one query? What is the best way to do this?

Lets say I want to DELETE from table1, table2, table3, table4

and

UPDATE fields 1-5 on both table5 & table6

<?php
require('db.php');
 
mysql_query("DELETE FROM table1");
 
mysql_query("UPDATE table5 SET field1='', field2='', field3='', field4='', field5='' ");
 
mysql_close();
exit();
?>

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