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troubleshooting Question

451 4.4.0 Primary Target IP Address responded with:"421 4.2.1 Unable to Connect"

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I am working on an Exchange site (Mixed): 2 servers running 2003 and 2 servers running 2007.  The 2003 side is working fine, but the 2007 side cannot send email to internet recipients.  
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Sam PanwarFlag of India imageSr. Server Administrator

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