Perplexing Permission Issue

I have been working with Microsoft servers for awhile but I have to admit that I am completely stumped on this one.  Here's my scenario:

There is a network application installed on my server, where the executable folder is shared out to the appropriate users.  The client installs the client side of the app to their computer which creates a shortcut to the executable on the server.  

Here's what I can't figure out.  I have a user john.doe, that has been granted the appropriate permissions on that executable folder and he can launch the executable with no problem from any computer over the network EXCEPT...from another server.  If I logon to another 2003 R2 server locally or by terminal services under john.doe's credentials and try to access this executable, which is located on a another server I get the following error: "Windows cannot access the specified device, path, or file.  You may not have the appropriate permissions to access the item".  From any other computer on the network I can launch the executable by using the UNC path.

Any suggestions?  Thanks.
phcc75Asked:
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Compaq_EngineerConnect With a Mentor Commented:
Does the server have the Internet Explorer Enhanced Security  installed?  We have to uninstall this on our terminal servers to allow several programs to run.
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phcc75Author Commented:
That was it!!!  I would have never have guessed that.  Who would ever have guessed that an IE setting would interfere with network permissions!  Thanks
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