Backup Exec 12 Failing to backup Exchange Servers

Every night our Backup server runs a backup to disk that seems to fail when trying to backup either of our Microsoft Exchange servers.  There is a weekly tape backup that has the same backup selection but it runs over the weekend. The tape backup doesn't have this issue.  I have tried the suggested resolution given by Symantec (http://seer.entsupport.symantec.com/docs/290493.htm) but this seems to have had no impact.  

System Info:
Windows Server 2003 Standard SP2
Symantec AntiVirus 10.1.5.5000
Dual 3GHz Intel Xeon
4GB RAM
5  1.5TB Drives (One for each weekday)

I have included a snippet of the log file.
[10060] 06/11/08 04:42:25 
T:\Backup2Disk\IMG000542\priv1.edb, buf=00000000, Size=00001000, 00000003:A5A17000
[10060] 06/11/08 04:42:25 
** Failed Machine contains MessageId=00000000:0000394B **
[10060] 06/11/08 04:42:25 
CurFile->Name = T:\Backup2Disk\IMG000542\priv1.edb
[10060] 06/11/08 04:42:25 
  Func=0175C3E0
  CurrentOffset=00000003:A5A17000
  CurrentBlockEnd=00000003:A5A18000
  RangeFirst=00000003:A5A17000
  RangeLast=00000003:A5A17FFF
  ReadRequestSize=00000000:00001000
  SizeToWrite=00000000:00001000
  MessageId=00000000:0000394B
  Overlapped=00000003:A5A17000
  Msg.MsgType=00000004
  Msg.Size=00001058
  Msg.FileId=00000003
  Msg.Length=00000000:00001000
  Msg.Offset=00000003:A5A17000
  Msg.CurrErr=00000000
[10060] 06/11/08 04:42:25 
ReadFile failed, lastError = 000005AA
[10060] 06/11/08 04:42:25 
Aborted state machine
[9612] 06/11/08 04:42:55 JetExternalRestore(2) - ERROR::RC = -1022 - -1022 There is a disk IO error.
[9612] 06/11/08 04:42:55 StopVirt FAILED!  RC = 1450 (0x5aa) - Insufficient system resources exist to complete the requested service.
[9612] 06/11/08 04:42:55 Using EDB Provider for Browse/Backup.
[9612] 06/11/08 04:42:55 Logon: m_lpMAPISession->Logon returned 80004005
[9612] 06/11/08 04:42:55 	FILTER DRIVER OPEN SESSION FAILED: Insufficient system resources exist to complete the requested service

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woodinvillelbrAsked:
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woodinvillelbrConnect With a Mentor Author Commented:
Unsure why but the issue has gone away
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Gary Fuqua, CISSPOwnerCommented:
This is a guess, but you may want to try to adjust settings to cache volume and cache file size using the Advanced Open File Option Wizard.  
They may be too large.  
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woodinvillelbrAuthor Commented:
I am currently not using the Advanced Open File Option.
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Gary Fuqua, CISSPOwnerCommented:
Is the disk an NTFS volume or FAT32?.    I have found that NTFS volumes work better.  
It is easy to convert it from FAT32 to NTFS in the Computer Management/Disk management console if this is the case.
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Gary Fuqua, CISSPOwnerCommented:
I should clarify.   The destination disk should be an NTFS volume.
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woodinvillelbrAuthor Commented:
The Storage volume and the OS volume are all currently formatted NTFS.
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Gary Fuqua, CISSPOwnerCommented:
Have you tried a different portable HD?     I had a situation where one of three portable hard drives simply refused to work.   Replacing the stubborn drive solved the problem.
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woodinvillelbrAuthor Commented:
This is going into a 9 TB Enterprise level SAN split into 1.5 TB drives.  It has worked for the last year and a half.
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KettleyCommented:
How I fixed the problem.

First:
Download and Installed this on The Exchange Server.
                Microsoft Exchange Server MAPI Client and Collaboration Data Objects
Second:
Installed this on the Backup Server.
            Exchange Management Tools for Microsoft Exchange Server
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