I have different Outlook 2007 signatures setup and I want to be able to have a signature inserted depending on the FROM account I select. I know about the insert signature button but I DON'T want to use that. I want to be able to set the signature using a Rule or Code or something. Let's say I am sending an email from the firstname.lastname@example.org so I want to use the Sales Signature. If it's my personal account I want it to use email@example.com. I am connected to an Exchange server and I use the FROM in a new email message because I have 'send on my behalf' permissions. I don't want to send my personal signature on a firstname.lastname@example.org email. By the way, I have more than just two signatures. Maybe a macro or something that fires after I select the FROM account.