Given the following diagram if one of the controls change enable save button.

I got something like this:
 private bool onLoad = true;

        public Form1()
        {
            InitializeComponent();
            BuildStatBar();
            EnableSaveButton();
        }

        private void EnableSaveButton()
        {
            rbtnInitialPriceOption.CheckedChanged += new EventHandler(CheckedChanged);
            rbtnAdjustmentPriceOption.CheckedChanged += new EventHandler(CheckedChanged);
            rbtnInterimPaymentOption.CheckedChanged += new EventHandler(CheckedChanged);
            rbtnFinalPaymentOption.CheckedChanged += new EventHandler(CheckedChanged);

            chkboxBarley.CheckedChanged += new EventHandler(CheckedChanged);
            chkboxDesBarley.CheckedChanged += new EventHandler(CheckedChanged);
            chkboxDurum.CheckedChanged += new EventHandler(CheckedChanged);
            chkboxWheat.CheckedChanged += new EventHandler(CheckedChanged);
     
        }

        protected override void OnActivated(EventArgs e)
        {
            onLoad = false;
        }

        private void CheckedChanged(object sender, EventArgs e)
        {
            if (!onLoad)
            {
                Control c = (Control)sender;
                if (c.Focused)
                {
                    MessageBox.Show("Changed");
                }
            }
        }

I have not tested it yet but we need to check if the person the txtListName has changed?

private void Form1_Load(object sender, EventArgs e)
        {
            sbPnlMsg.Text = "";
            LoadInitialPriceReporting();
            BuildStatBar();
            HideTabs();
            EnableSaveButton();
        }

        private void EnableSaveButton()
        {
            rbtnInitialPriceOption.CheckedChanged += new EventHandler(CheckedChanged);
            rbtnAdjustmentPriceOption.CheckedChanged += new EventHandler(CheckedChanged);
            rbtnInterimPaymentOption.CheckedChanged += new EventHandler(CheckedChanged);
            rbtnFinalPaymentOption.CheckedChanged += new EventHandler(CheckedChanged);

            chkboxBarley.CheckedChanged += new EventHandler(CheckedChanged);
            chkboxDesBarley.CheckedChanged += new EventHandler(CheckedChanged);
            chkboxDurum.CheckedChanged += new EventHandler(CheckedChanged);
            chkboxWheat.CheckedChanged += new EventHandler(CheckedChanged);
     
        }

Hi,

for the textbox you use the textchanged event:

textBox1.TextChanged += new EventHandler(CheckedChanged);

cool.