The works on my Citrix Presentation Server 4.0 (W2k3) when I paste it into a Start, Run prompt:
excel.exe "S:\CR 716XXX 2008 06 24 TEMPLATE.xls"
But I get nothing when I click on the Citrix application icon from a client. In the Citrix "Application Location" configuration, I have the above line in the "Command Line". Citrix Help doc is not much help on syntax.