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ASP Net - Failed to execute request because the App-Domain could not be created. Error: 0x8013150a - I am recieving, can you help

I am having a issue running a ASP application that is passing files, the error I get is
ASP Net - Failed to execute request because the App-Domain could not be created. Error: 0x8013150a

I have enable IIS_WGP permissions to the webroot and the application to full control, with no success
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rahknights
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rahknights
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60MXGCommented:
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