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How do I remove virus/trojan from my infected server

I have windows Server 2003 enterprise edition, after infected by virus/trojan, its task manager and registery editor disabled and on network when I search this server gives below error message;
\\server is not accessible.  You might not have permission to use this network resource.
Contact the administrator of this server to find out if you have access permissions.
Logon Failure:  The user has not been granted the requested logon type at this computer.

When I enable task manager and registery editor by gpedit.msc, after some time it automatically disabled again. I have scanned server by Norton corporate 10 but could not detect any virus. How do I resolv this issue and prevent other servers from infection.
Anti-Virus AppsMicrosoft Server OSWindows Server 2003

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8/22/2022 - Mon