The User Profile Service failed the logon. User profile cannot be loaded.

Thank you leegclystvale!  My Windows 2008 domain\administrator profile got corrupted when I shutdown my Windows 2008 64-bit server accidently using another domain account that had administrative rights.  Then I could not login to my server with my domain\administrator account.  I could only login as the user with the administrative rights, which messed up all the services that used domain\administrator logon credentials.  When I brought it up in safe mode as domain\administrator, the system said that the profile was bad and used the default profile.  So, I brought up the system normally and logged in as the user with administrative rights and went into regedit to look for the key you mentioned.  However, I had to go to HKLM\Software\Microsoft\Windows NT\Current Version\ProfileList\ instead of Current User\ProfileList and saw that there were two identical sids.  One with a .bak extension and one without.  When I looked at the one without the extension, it was set to C:\Users\temp and didn't have much in the key.  When I looked at the .bak sid, it was the original domain\administrator sid and had the directory pointing to c:\users\administrator like it was supposed to be. So, I renamed the sid without the extension to .bad and I removed the .bak from the original sid.  Then I changed the State property in the right pane (of the sid that I just removed the .bak) to 0 (zero).  Then I logged off as the user with administrative rights and then I was able to successfully login as the domain\administrator again and had my original profile back!  Thanks again for this tip.  I thank God for leading me to this one because it helped me dodge a major bullit.

Cool. Glad it helped :o)

Thank YOU ContrAcct!  You saved me and my Co. from much struggle with this!  your solution worked a treat on our production TS.

This issue can also be caused if your Default user is corrupted. In order to see the default user folder you will need to change your view to include hiden system files.  First rename the old one on your current server to .old. Try to find a default user from the same version of Windows 2008 and copy it to the users directory.

Maudeeb618

We also had this problem, on a Production Exchange 2010 machine running Windows 2008 R2 Enterprise 64-bit.  Deleting the Default folder under Users and copying a fresh one from another system (same OS) solved the issue for us.  (We had to log on as the local Administrator to make this happen.)

I  have tried doing this but the issue gets temp resolved and the same users is having the issue.
1.Removed the SID or the user from HKLM\Software\Microsoft\Windows NT\Current User\ProfileList\
2.Renamed the user folder to .OLD
3.Tried to login again still not working
I used to follow the above process to resovle the issue in past it used to get resolved but now its not.
I suspect this could be problem with Terminal server itself.
 TS is 2008 Service pack2.

I have a similar issue to this, however the issue occurs for users that haven't yet logged onto the system.

There are three users that have profiles on the machine, then three more admin - none of the new admin can log on.

Any ideas?

Had one user that had not yet logged in to that server, so after trying all the "normal" fixes, I manually created the folder, set the permissions and now they can login. Weird.

you can restore to previous date in safe mode, to fix the issue. user profile service failed