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Exchange Information Store fails to open when primary DC is down

We have 2 domain controllers in 2 different physical locations. Our exchange server is at the same location as one of them. When that DC failed (SCSI controller), our entire Exchange stopped working. It appears the information store is inaccessible, even though I verified it IS stored locally on the Exchange server. So nobody can use Outlook (unless in cached mode, but no new e-mails) or OWA. Is there a work around? How can we resolved this so it continues to work. Everything else in the network "fails over" to our other domain controller.

Please help!!
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bcrosby007
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How do I do that?
Go to Active Directory Sites and Services. Drill down to your servers (you should have 2 if you have to domain controllers). Click on one of the servers. On the right pane, right click on NTDS Settings and choose properties. There will be a Global Catalog check box there. Make sure it is checked on both servers. If it is not on one of the servers, check it and then restart that server.
Thanks! I found that checkbox and it was not checked. I checked it and rebooted the server. I'll let you know if that solves our problem! Thanks so much!
Do you get any events such as MSExchangeDSAccess in your application logs ? 2102 / 2103 / 2114 ?
Is the DC you are talking about the only GC? If yes please go to the above location and ensure you make the other server as a GC - Don't forget to reboot that as soon as you make that a GC.

Which servers are listed as your primary DNS and secondary DNS server ?
My guess would be you have only one that would be your first DC - ensure you have a second DNS configured.
Thank you very much! This was the issue and everything is working great now. Our primary DC is completely off and we are still working 100%.